PeriIont for Laser Doppler Flowmetry (LDF)

PeriIont Micropharmacology System

Iontophoresis is a technique to transport charged molecules or drugs across a tissue barrier. Combined with the laser Doppler or laser speckle techniques, iontophoresis is a valuable tool for diagnosis and studying endothelial dysfunction. 1Roustit et al, Assessment of endothelial and neurovascular function in human skin microcirculation, Trends in Pharmacological Sciences, 2013, 34(7):373-84

Iontophoresis is a technique that can be used to transport drugs in ionic form across intact skin. Depending on the chosen drug, this may or may not affect the local blood perfusion. The technique is based on the principle that an electric potential will cause ions in solution to migrate according to their electrical charges.

The PeriIont Micro Pharmacology System is an iontophoresis system that can deliver minute volumes of drugs non-invasively in a controlled fashion. Together with the laser Doppler or the laser Speckle (LASCA) technique, the vascular responses to the drug can be studied while it is being delivered. The PeriIont Micro Pharmacology System is a useful system for studying endothelial dysfuction, and it is available for the PeriFlux System 5000 and the PeriCam PSI System.

PeriIont Micropharmacology System

The PeriIont Micropharmacology System is a versatile accessory to study microcirculatory responses to non-invasively delivered drugs. The system is offered as a complete kit with everything you need to start the measurements.

Endothelial Dysfunction

Iontophoresis is an excellent method to study the endothelium and assess the subject’s endothelium dependent and endothelium independent vasodilation.

Features PeriFlux System 5000/6000 Features PeriCam PSI NR
Single-point monitoring. Imaging of larger area.
Low volumes of drug solution needed. Transparent drug delivery chamber.
Standardized skin temperature during experiment. Calculation of flare statistics.

References:

  1. Roustit et al, Assessment of endothelial and neurovascular function in human skin microcirculation, Trends in Pharmacological Sciences, 2013, 34(7):373-84

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